Nimesil in gynecology for inflammation


Pronounced pain during menstruation in medical practice called algomenarea and are found in more than 50% of women. To prevent such a pathology, experts recommend to their patients a large selection of medications, including nimesil during menstruation.

Pain syndrome during menstrual bleeding adversely affects the physical and psychological state of patients. But not all drugs can be used to relieve such pain. Why precisely nimesil recommend specialists women in the presence of such problems?

Read in this article.

Pharmacological properties

Nimesil is considered a pronounced representative of nonsteroidal anti-inflammatory drugs. It belongs to the family of sulfonamides, and due to the blockade of the release of prostaglandins in the female body effectively relieves pain.

The biologically active substance of the medication in question is nemusulide, and to improve the taste and increase the absorption rate of the drug in the gastrointestinal tract, pharmacological companies add a number of specific additives to the final product.

Experts believe that the main pharmacological action of nimesil is a negative and blocking effect on the synthesis of arachidonic acid. This leads to a decrease in the release of prostaglandins and a reduction in pain. A similar effect of the drug on the body is used when it is recommended that women use nimesil for painful periods.

In addition, the mechanism of the anti-inflammatory action of the drug is described, which is facilitated by the ability of the drug to prevent the formation of free radicals.

When and how doctors recommend using nimesil

The considered drug is widely used to reduce pain in various pathologies. Most often this drug is recommended:

  • If the patient has undergone surgical or gynecological surgery, then nimesil include in the course of postoperative therapy.
  • Various traumatic pathology also requires the use of this drug. When bursitis, arthritis and other diseases of the joints use not only the anesthetic effect of the drug, but also its high anti-inflammatory activity.
  • There is a wide field of activity for nimesil in patients with otorhinolaryngological and dental problems.
  • Well, of course, dysmenorrhea. Pronounced pain during menstruation, modern medicine offers to treat only non-steroidal anti-inflammatory drugs, of which nimesil is considered one of the most effective and safe.

The dosage of the drug should not exceed 200 mg, that is, 1 sachet per reception, 2 times a day. This is due to the effect of the drug on the gastric mucosa. It is also not recommended to use this drug for more than 2 weeks, however, for patients with painful menstruation, this is not very relevant.

But this drug cannot be said to be a panacea for women with menstrual problems. Like most nonsteroidal anti-inflammatory drugs, nimesil has its own contraindications and side effects.

Possible adverse reactions

Most often, if you use nimesil with monthly pain, the following adverse pathological manifestations are possible:

  • On the part of the gastrointestinal tract, women often report nausea, vomiting, and abdominal pain. Sometimes the situation may be aggravated by the development of gastric or intestinal bleeding.
  • The cardiovascular system on the use of this medication may respond to lower blood pressure, tachycardia, in rare cases, heart rhythm disturbances.
  • Quite often suffers and the central nervous system. With a similar pathology, women may complain of dizziness, headache, drowsiness, and apathy.
  • Non-steroidal anti-inflammatory substances can cause changes in blood tests. Experts note the possibility of anemia, eosinophilia, marked increase in liver function tests.

In addition to various side effects, an overdose of the drug often occurs by patients, as the woman seeks to maximize pain relief and exceeds the allowed dose. In this case, the main symptoms will be observed from the gastrointestinal tract, since, due to its pharmaceutical characteristics, the drug primarily affects the walls of the stomach and intestines.

In most cases, the matter does not reach the bleeding, and the symptoms are limited to vomiting, pain in the stomach, drowsiness and a drop in blood pressure. Nimesil has no special antidotes, and first aid consists in washing the stomach, taking activated carbon and immediately seeking qualified medical help.

We recommend reading the article on the MIG medication during menstruation. From it you will learn about the effect of the drug and the indications for its use, contraindications and possible side effects, effectiveness with painful menstruation.

Short list of contraindications

When a woman begins to take nimesil during menstruation, she should first consult a doctor. There she will be told that this drug is contraindicated for use for a large number of patients with various chronic diseases. This list includes:

  • Diseases of the digestive tract. If a patient has chronic gastritis or has a history of gastric ulcer, then this drug is contraindicated to reduce pain.
  • It is strictly forbidden to use nimesil to people suffering from hepatic or renal insufficiency in any form.
  • The drug is banned in patients with impaired blood coagulation system. Any bleeding is a direct contraindication to the use of nimesil.
  • As noted above, this drug adversely affects the work of the cardiovascular system, therefore, for women suffering from similar disorders, it is contraindicated.

And, of course, you should remember about the possibility of serious allergic reactions to the use of this medication. If the patient already had problems with taking nonsteroidal anti-inflammatory drugs or acetylsalicylic acid, then it is better to refrain from nimesil.

Due to its relatively high toxicity, this medicine should not be given to pregnant women in the 1st and 3rd trimester, it is not recommended during lactation. If a woman asks a doctor if nimesil can be taken during menstruation, a specialist should familiarize her with all the side effects of taking this drug.

Nimesil for painful menstruation

This drug has many advantages over analgesics. First of all, experts note that if you drink Nimesil, the powder with menstruation has an almost instant analgesic effect. This is explained by the fact that after 10–15 minutes the concentration of the drug in the patient’s plasma reaches almost 75% of the maximum dose.

This ability of Nimesil to be quickly absorbed allows you to relieve severe pain during menstruation for 5 to 8 hours, which is inaccessible to most modern analgesics. Of course, here we are not talking about narcotic analgesics.

Non-steroidal anti-inflammatory agent is usually recommended for patients to start drinking 2 to 3 days before the expected onset of menstruation. Since the annotation indicates the deadline for taking nimesil 14 days, then the woman will have enough time to go through the most difficult period of the menstrual cycle.

When a question arises in women whether nimesil helps with menstruation, the answer, of course, will be only positive. This is one of the most reliable ways to deal with pain at the time of menstruation.

However, most experts recommend, given the side effects of this drug, not to get involved in monotherapy, but to combine the use of nonsteroidal anti-inflammatory drugs with other drugs. In this case, the best baralgin or no-shpa. A good effect can be obtained by using nimesil and analgin simultaneously. The relief of pain with such treatment will be faster, and the negative effect of nimesil on the walls of the stomach and intestines will be reduced.

Look at the video about the causes of painful periods:

Drug cost

In the modern pharmacy network, this medicine is mainly represented by German and Spanish manufacturers. The retail price in the Russian Federation ranges from 500 to 800 rubles, depending on the region. In Ukraine, the cost of nimesil in most pharmacies is 220-250 hryvnia per pack of 30 bags.

The use of the drug should not be without the supervision of a physician. Nimesil has an excellent effect on pain relief during menstruation. At the same time it is quite a serious and dangerous drug. It is better to consult a specialist than to treat the consequences of unauthorized use of a nonsteroidal anti-inflammatory drug.

Release form

Nimesil is produced in the form of granular granules for the preparation of suspensions for oral administration, having a light yellow color and an orange smell. In one paper laminated bag - 2 grams of powder. Cardboard packs on 9, 15, 30 bags.

  • 1 bag of 22-40 rubles,
  • 30 bags 611-890 rub.

pharmachologic effect

Nimesulide has a pronounced effect on the metabolism of arachidonic acid, inhibiting mainly cyclooxygenase-2. Owing to these processes, the biosynthesis of prostaglandins, which mediate inflammatory and allergic reactions and affect the smooth muscle of the organs, is reduced.

The drug quickly blocks the release of histamine from mast cells, slows down the synthesis of metalloprotease, elastase and collagenase, thereby protecting cartilage tissue from destruction. Suppresses the release of tumor necrosis factor alpha, reducing the effect of kinins, causing expansion of the vascular wall. Reduces the production of superoxide anions by neutrophils and the formation of free radicals, which play an important role in the development of the inflammatory response.

Due to the nature of this dosage form of nimesulide, the effectiveness of Nimesil develops quickly and lasts for 6 hours.


According to the instructions for use of Nimesil after taking the suspension, the drug is quickly absorbed through the gastrointestinal tract, reaching a maximum therapeutic concentration in 2-3 hours. It is characterized by a high bond with blood proteins, up to 97.5%, easily passes through histohematogenous barriers.

Metabolism of the drug occurs in the liver using P450 (CYP) 2C9: cytochrome isoenzyme. The main metabolite is hydroxynimesulide, a pharmacologically active derivative of nimesulide. Excreted through the bile in a metabolized form.

About 50% of the accepted amount of Nimesil is excreted by the kidneys.

Drug interactions

Requires an individual assessment of the risk-benefit of Nimesilom therapy while taking angicoagulants (warfarin), antiplatelet agents (clopidogrel), glucocorticosteroids (Prednisone), selective serotonin reuptake inhibitors SSRIs (Citalopram, Sertralin).

Pain is considered to be one of the most frequent symptoms of the disease in gynecology requiring assistance. It appears as a result of irritation or inflammation of the serous integument, as well as muscle spasm (smooth) of hollow organs and as a result of impaired blood circulation in the internal organs. Pain in most cases causes a woman to consult a gynecologist. In women, hormonal disorders are often accompanied by menstrual disorders. Algomenorrhea is a strong pain in the period of menstruation is one of the violations of the menstrual cycle. At the same time, the pains are so intense that the working capacity is completely disturbed and the woman just has to be at home several days of each month. The use of the drug nimesil remarkably relieves pain of a different type in gynecology, or significantly reduces their intensity.

The drug nimesil - his actions

Nimesil refers, as a rule, to nonsteroidal anti-inflammatory drugs of the current generation. A feature of these drugs is that they have much less side effects on the coagulating ability of the blood and the gastrointestinal tract.

One of the undeniable advantages of nimesil is the dosage form, due to which this drug is quite quickly, almost fully absorbed. For example, half an hour after taking the drug (100 grams), its plasma content will already reach 50% of the maximum concentration. Its principle of action is to suppress the synthesis of prostaglandins. The duration of one dose of nimesil corresponds to 6 hours. It is approximately for such a period of time with gynecological diseases that pain will not disturb a woman. Also, this drug with long-term use is well tolerated, has a relatively short half-life.

Contraindications and side effects of the drug nimesil in gynecologists

Despite the relatively high degree of safety, the drug nimesil is not recommended to be used during pregnancy, with lesions of the gastrointestinal mucosa of various kinds, for diseases of the liver and kidneys, as well as in case of intolerance to some of its individual components. The use of Nimesil is not recommended for girls under 12 years old.

Due to the systemic action of nimesil powder, side effects can affect all vital systems in the body. A sedative effect on the nervous system is possible, which can cause migraine attacks, dizziness and drowsiness in a woman. Anomalies of the digestive system are expressed by pain in the stomach, dyspeptic symptoms and nausea. In quite rare cases, there is a change in blood formulas, allergic manifestations on the skin and urinary retention.

In the case of an overdose of the drug nimesil observed in some women, an increase in all side effects. There is no specific antidote, and the treatment involves, first of all, cleansing the stomach from harmful substances and taking sorbeks or as sorbents of activated carbon. The patient in this case needs constant supervision of specialists, until the general condition is satisfactory.

Pronounced pain during menstruation in medical practice called algomenarea and are found in more than 50% of women. To prevent such a pathology, experts recommend to their patients a large selection of medications, including nimesil during menstruation.

Pain syndrome during menstrual bleeding adversely affects the physical and psychological state of patients. But not all drugs can be used to relieve such pain. Why precisely nimesil recommend specialists women in the presence of such problems?

general characteristics

"Nimesil" refers to nonsteroidal anti-inflammatory drugs. Like all drugs in this group, it has antipyretic and analgesic effect, reduces inflammatory processes. Nimesil is not a specific cure for any disease. Its purpose is to eliminate the symptoms. Any person may need to take this medicine, so everyone needs to know how to drink Nimesil.

The drug is mainly prescribed by doctors for various pathologies, accompanied by pain or fever. But it is used only in complex treatment, because without getting rid of the cause that caused such a condition, the patient’s suffering can be alleviated only temporarily.

Composition and release form

The active ingredient of the drug is nimesulide, which belongs to the sulfonamide group. Its advantage over other nonsteroidal anti-inflammatory drugs is the speed of action and lasting 6-hour effect. Therefore, it is enough to take the drug twice a day. In addition to the main active substance, maltodextrin, ketomacrogol, sucrose, citric acid and orange flavor are included in this product.

Due to the special form of release, Nimesil is simple to take, it is quickly absorbed into the blood and rarely has a negative effect on the gastrointestinal tract. A product is produced in powder for the preparation of a medicinal solution. It has a light yellow color and a pleasant orange aroma. The powder is packaged in sachets of 2 g. This dose is often sufficient for one administration in any pathology and for patients at any age.

What effect does "Nimesil"

This drug has a strong analgesic, antipyretic and anti-inflammatory effect. Nimesulide is valid for 6-8 hours after administration. During this time, it penetrates into many tissues and body fluids, even into breast milk. Therefore, it is impossible to take "Nimesil" when breastfeeding.

Как многие нестероидные противовоспалительные препараты, это лекарственное средство воздействует не на очаг боли, а на синтез определенных гормонов и ферментов и блокирует их, приостанавливая развитие воспалительного процесса в организме. But unlike other drugs, such as Aspirin or Ibuprofen, it does not reduce the production of enzymes that protect the gastric mucosa from hydrochloric acid. Therefore, it is imperative to know how to drink Nimesil correctly to avoid side effects. The most common disorders of the digestive system.

The drug "Nimesil": indications for use

This is one of those remedies that are often prescribed for colds to reduce fever and relieve pain. The drug helps with toothaches and headaches caused by various reasons. Nimesil is also often used for neuralgia. In addition, due to the peculiarities of its action and the possibility of long-term use, it is more often used in the pathologies of the musculoskeletal system. The list of pathologies for which this drug is effective includes:

  • infectious and inflammatory diseases,
  • Colds
  • sprains,
  • myalgia
  • joint pain,
  • osteochondrosis, spondylosis, radiculitis, intervertebral hernia,
  • injuries of bones and joints,
  • osteoarthritis,
  • tendonitis, bursitis, arthritis,
  • toothache,
  • cystitis, gynecological diseases,
  • algomenorrhea,
  • postoperative pain syndrome.

Nimesil powder: instructions for use

The drug is not available in tablets. It is a granule for the preparation of a medicinal solution. Therefore, it has special rules of application. Some people cannot swallow capsules and tablets, so a nice orange-flavored drink will be a comfortable solution for them.

But you need to know how to properly drink Nimesil, so that it acts and does not have side effects. It is recommended to pour one packet of the drug into a glass and pour 100 ml of drinking water. It should not be hot, you can take warm boiled. After complete dissolution of the drug should be immediately drink. Store the solution can not, it is prepared immediately before use. And to protect the gastrointestinal tract from the damaging effects of the components of the product, it is recommended to drink the medicine after a meal.

Drug dosage

Usually with various pathologies prescribed "Nimes" powder. The instruction describes in detail the dosage at which it can be taken, but sometimes the doctor makes his own adjustments. This drug is prescribed at any age older than 12 years, 1 sachet 2 times a day. It is recommended that the interval between doses should be at least 6-8 hours. In the most severe cases, for example, at high temperatures with the flu or during the postoperative period, it is possible to take 3 sachets per day.

You need to know how often you can drink Nimesil powder. This medicine is well suited for a single dose in case of acute pain, as well as for long-term therapy for chronic pathologies. But if within 3 days there was no improvement in the patient’s condition, it is necessary to consult a doctor. In general, daily administration of the drug is possible only during the week. Doctors often recommend taking it every other day, combining with other means. However, such tactics of treatment should be followed only after consulting a doctor.

Overdose of Nimesil

The drug is excreted after 6-8 hours after administration. Therefore, the use of the next bag earlier may cause various complications associated with overdose. The same condition is possible for those who take more than one sachet at a time or drink Nimesil for a long time. In fact, if you immediately drink a large dose, it will not lead to an increase in the effect of the drug.

Symptoms of an overdose may be:

  • nausea, vomiting, abdominal pain,
  • high blood pressure
  • drowsiness, apathy,
  • shortness of breath, anaphylactic shock,
  • stomach bleeding,
  • renal failure
  • in the most severe cases, the patient may fall into a coma.

If, after a single dose of a large dose, an overdose symptoms appear, you just need to refuse to take the drug and consult a doctor. If relief does not come, you need to wash the stomach, take a laxative and activated charcoal. With a serious overdose, medical assistance and monitoring of the liver and kidneys are necessary.

Features of use in some pathologies

In addition to the need to adjust the dosage of the drug for people with various chronic diseases, there are features of its use in various pathologies.

  • The most commonly used "Nimesil" for diseases of the spine and joints. Doctors prescribe it for radiculitis, hernia, osteochondrosis, after injuries. It is imperative to find out how to drink Nimesil in bags under such conditions correctly. After all, overdose or misuse can cause serious side effects.
  • Effective "Nimesil powder for toothache, especially after the removal procedure. But before dental treatment, doctors do not recommend taking it. After all, the drug causes insensitivity to pain, so it will be difficult to make the correct diagnosis. In addition, it violates blood clotting.
  • Often used "Nimesil" for colds and flu. It quickly lowers the temperature, reduces the severity of pain, reduces inflammation. This drug even helps to reduce tearing and nasal congestion. But it only relieves the symptoms, and does not cure the underlying disease.
  • Many women suffer from severe pain during menstruation. In medicine, this condition has been called "algodisminorrhea." Abdominal cramps are difficult to remove, but it is effective for menstrual pain "Nimesil." He has almost instant action - after 20 minutes, the woman feels relieved. The result lasts for several hours, after which it is possible to drink another sachet, but usually this is not required, since the pain does not return. You can prevent the emergence of severe pain, if you start to drink "Nimesulide" for a couple of days before the start of menstruation.

Side effects

Usually, Nimesil is easily tolerated, especially if taken correctly. But in some patients the following side effects are possible:

  • anemia, thrombocytopenia, bleeding disorders,
  • nervousness, insomnia, anxiety,
  • headaches, dizziness,
  • increased heart rate
  • high blood pressure
  • nausea, vomiting, abnormal stool, flatulence, abdominal pain,
  • abnormal liver function, jaundice,
  • hyperkalemia,
  • allergic reactions up to anaphylactic shock or angioedema,
  • reduced visual acuity
  • bronchospasm, difficulty breathing,
  • renal failure, urinary retention.

If such negative reactions occur, you should stop taking the drug, and patients with chronic pathologies of the kidneys, liver or stomach after prolonged use are advised to consult a doctor for a preventive examination, since Nimesil may cause their exacerbation.

Contraindications to the drug

Like all nonsteroidal anti-inflammatory drugs, Nimesil can not be taken by everyone. There are many absolute contraindications and conditions in which it is not recommended to drink it:

  • bronchial asthma, urticaria, allergies,
  • hypersensitivity to NSAID drugs,
  • after coronary artery bypass surgery,
  • recurrent gastric ulcer or gastritis,
  • renal failure
  • abnormal liver function
  • type 2 diabetes
  • bleeding,
  • pregnancy planning,
  • drinking alcoholic beverages
  • bleeding disorder,
  • cardiovascular failure
  • children's age up to 12 years.

In addition, you can not take "Nimesil" with breastfeeding and during pregnancy. Nimesulide adversely affects the development of the fetus due to the fact that it can cause impaired renal function, closure of the arterial duct, the occurrence of bleeding and peripheral edema. With caution it is also worth drinking "Nimesil" for people with chronic diseases of the gastrointestinal tract. For elderly patients, the dosage is calculated individually.

Interaction with other drugs

Not all patients know how to drink "Nimesil" with complex therapy. In this case, it is desirable that all drugs be prescribed by a doctor. After all, nimesulide weakens or enhances the effect of various drugs. For example, it increases the concentration of lithium in the blood, may enhance the effect of "Furosemide", "Cyclosporine", as well as anticoagulants. Nimesulide should not be taken together with other nonsteroidal anti-inflammatory drugs, especially with Paracetamol and Aspirin.

The risk of side effects increases if this drug is drunk by people who are treated with sulfonamides, Methotrexate, diuretics. When using Nimesulide together with diuretics, the effect of the latter is reduced, since the drug causes fluid retention in the body.

Drug reviews

Most doctors and patients speak positively about this tool. When properly administered, side effects are rarely observed. Doctors like Nimesil's high efficacy and good tolerability. Patients note ease of use, quick results and lasting effect. Need to drink only 1-2 sachets per day. It is very convenient for chronic pathologies, accompanied by prolonged pain. Many take Nimesil for a long time, sometimes taking breaks. With severe pain, you can drink it 1 time in 2-3 days, which will allow you to feel relief and at the same time will not cause adverse reactions.